FIG. 1.

Attenuation of diet-induced obesity in Grp78^+/− mice. A: Fasting body weight on regular diet (RD) or HFD from 10-week-old mice (n ≥ 7 mice per condition). ○, ^+/+ HFD; ●, ^+/− HFD; ▵, ^+/+ regular diet; ▴, ^+/− regular diet. B: Body size after 20-week HFD. C: Body composition after 11-week HFD. n = 9 (^+/+, □) or 6 (^+/−, ■). D: Food intake measurement. n = 7 (^+/+, □) or 5 (^+/−, ■). E: Oil Red O staining of stool smear from mice on HFD. Negative control: dH₂O; positive control: white adipose extract. Data are presented as the means ± SE. *P < 0.05; **P < 0.01 for ^+/− vs. ^+/+. (A high-quality color digital representation of this figure is available in the online issue.)