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. 2009 Oct 6;59(1):6–16. doi: 10.2337/db09-0755

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 4. — Grp78 heterozygosity improves insulin sensitivity independently of adiposity. A–C: Hyperinsulinemic-euglycemic clamp studies on 13-week-old ^+/+ (n = 5) and ^+/− (n = 4) mice on regular diet (RD). A: Body composition. B: GINF. C: Whole-body glucose turnover and glycolysis during clamps. D: Immortalized Grp78^+/− and ^+/+ MEFs were treated with insulin (100 nmol/l, 15 min) following 5-h serum starvation. Whole cell lysates were subjected to Western blot for phosphorylated (Ser473) and total AKT. Lanes were run on the same gel but noncontiguous. E–H: For 13-week-old mice on regular diet or after 3-week HFD. E: Fasting body weight (HFD). F: Blood glucose (regular diet and HFD). G: Blood insulin (regular diet and HFD). (E–G: n ≥ 6 mice per condition.) H: Insulin tolerance test (HFD). n = 4 (^+/+, ○) or 5 (^+/−, ●). Data are presented as the means ± SE. *P < 0.05; **P < 0.01 for ^+/− vs. ^+/+. □, ^+/+; ■, ^+/−.