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. 2009 Oct 6;59(1):6–16. doi: 10.2337/db09-0755

FIG. 5.

FIG. 5.

Grp78 heterozygosity improves insulin sensitivity predominantly in WAT. A–E: Hyperinsulinemic-euglycemic clamp studies on +/− (■, n = 6) and +/+ (□, n = 9) mice after 10–11 weeks of HFD. A: Whole-body glucose metabolism indicated by GINF and clamp glucose turnover. B: Whole-body glycolysis and glucose anabolism during clamps. C and D: Glucose uptake by white adipose (C), skeletal muscle, and brown adipose (D) during clamps. E: Hepatic glucose production. F and G: Representative Western blots and quantitation of phosphorylation of IRS-1 (Tyr) and AKT (Ser473) in WAT of mice after clamps (n = 4 mice per genotype) (F) and JNK1 in WAT of 25-week-old mice on regular diet (RD) or after 15-week HFD (n = 3–5 mice per condition) (G). □, +/+; ■, +/−. Data are presented as the means ± SE. *P < 0.05; **P < 0.01 for +/− vs. +/+; ##P < 0.01 for HFD vs. regular diet.