FIG. 7.

Grp78 heterozygosity upregulates PGC-1α and GRP75 in WAT. Whole cell lysates from WAT of 25-week-old mice on regular diet (RD) or after 15-week HFD (n = 4–6 mice per condition) were subjected to Western blotting for PGC-1α (A) and GRP75 (B). In the representative blots, lanes that were run on the same gel but noncontiguous are divided by lines. Quantitative protein levels are presented as the means ± SE. *P < 0.05; **P < 0.01 for ^+/− vs. ^+/+; #P < 0.05; ##P < 0.01 for HFD vs. regular diet. □, ^+/+; ■, ^+/−.