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. 2009 Oct 16;33(1):17–22. doi: 10.2337/dc09-1502

Table 3.

Glycemic indices

Age ≥25 years (n = 74)*
 Age 15–24 years (n = 55)*
 Age 8–14 years (n = 44)*
Baseline (blinded) Month 6 P Baseline (blinded) Month 6 P Baseline (blinded) Month 6 P
Glucose (mg/dl) 157 ± 25 152 ± 18 0.08 165 ± 27 173 ± 28 0.02 172 ± 29 169 ± 28 0.50
    Minimum/day 71–180 mg/dl 882 980 <0.001 822 788 0.14 797 812 0.18
Hypoglycemia
    Minimum/day (mg/dl)
        ≤70 55 45 0.02 93 55 0.005 56 37 0.61
        ≤60 20 17 0.006 49 23 0.001 19 11 0.23
        ≤50 5 4 0.02 19 4 0.008 2 1 0.61
    AUC† 0.3 0.3 0.008 0.7 0.3 0.002 0.4 0.2 0.42
    LBGI 0.9 0.9 0.02 1.5 0.9 0.004 1.0 0.8 0.56
Hyperglycemia
    Minimum/day (mg/dl)
        >180 439 390 0.03 494 582 0.03 569 568 0.37
        >200 296 256 0.004 381 436 0.03 460 452 0.23
        >250 114 72 <0.0001 166 210 0.07 218 193 0.58
    AUC‡ 15.1 12.1 <0.001 21.7 25.0 0.06 25.3 23.9 0.43
    HBGI 6.8 5.8 0.002 8.2 9.4 0.04 9.6 9.6 0.45
Glycemic variability§
    SD (mg/dl) 60 54 <0.001 (<0.001) 67 68 0.35 (0.38) 66 66 0.61 (0.95)
    MAGE (mg/dl) 110 100 0.14 (0.35) 126 124 0.44 (0.38) 129 119 0.04 (0.06)
MARC (mg · dl−1 · min−1) 0.65 0.68 0.13 (0.03) 0.79 0.80 0.01 (0.16) 0.75 0.77 0.72 (0.49)
Coefficient of variation (%)‖ 38 36 0.002 (<0.001) 41 41 0.27 (0.32) 41 39 0.99 (0.90)

Data are means ± SD and medians unless otherwise indicated.

*n includes subjects with at least 24 h of data at both baseline and month 6.

†Total area <70 mg/dl, reflecting both percentage and severity of glucose values in the hypoglycemic range.

‡Total area >180 mg/dl, reflecting both percentage and severity of glucose values in the hyperglycemic range.

§For variability, the P values unadjusted and adjusted for mean glucose are both given: unadjusted (adjusted).

‖Coefficient of variation = SD/mean. AUC, area under the curve; LBGI, low blood glucose index (13); HBGI, high blood glucose index (13); MAGE, mean amplitude of glycemic excursions; MARC, mean absolute rate of change.