Table 3.
Associations of glucose, insulin, and HOMA-IR with the prevalence of adenoma and cancer in the colorectum
| Colorectal adenoma |
Colorectal cancer |
|||||||
|---|---|---|---|---|---|---|---|---|
| 1 (low) | 2 | 3 (high) | Ptrend | 1 (low) | 2 | 3 (high) | Ptrend | |
| n | 86 | 22 | ||||||
| Fasting glucose (mg/dl) | <100 | 100–108 | >108 | <99 | 99–108 | >108 | ||
| No. of case subjects/control subjects | 32/74 | 24/93 | 30/91 | 4/21 | 6/22 | 12/23 | ||
| Crude OR (95% CI)* | 1 | 0.57 (0.30–1.08) | 0.73 (0.39–1.36) | >0.2 | 1 | 1.69 (0.36–7.96) | 3.12 (0.76–12.74) | 0.09 |
| Multivariable OR (95% CI)† | 1 | 0.62 (0.32–1.19) | 0.76 (0.40–1.42) | >0.2 | 1 | 1.76 (0.35–8.69) | 4.40 (0.99–19.59) | 0.04 |
| Multivariable OR (95% CI)‡ | 1 | 0.62 (0.32–1.20) | 0.76 (0.41–1.44) | >0.2 | 1 | 2.17 (0.41–11.50) | 4.07 (0.86–19.37) | 0.07 |
| Fasting insulin (μU/dl) | <4.7 | 4.7–7.4 | >7.4 | <5 | 5–7.8 | >7.8 | ||
| No. of case subjects/control subjects | 29/85 | 29/83 | 28/90 | 5/21 | 8/22 | 8/23 | ||
| Crude OR (95% CI)* | 1 | 1.02 (0.57–1.85) | 0.91 (0.50–1.66) | >0.2 | 1 | 1.55 (0.45–5.32) | 1.38 (0.40–4.76) | >0.2 |
| Multivariable OR (95% CI)† | 1 | 1.14 (0.61–2.12) | 1.08 (0.58–2.03) | >0.2 | 1 | 1.65 (0.38–7.28) | 1.84 (0.47–7.15) | >0.2 |
| Multivariable OR (95% CI)‡ | 1 | 1.15 (0.62–2.15) | 1.15 (0.57–2.31) | >0.2 | 1 | 1.88 (0.39–9.03) | 1.29 (0.28–5.84) | >0.2 |
| HOMA-IR | <1.2 | 1.2–2.05 | >2.05 | 1.33 | 1.33–2.04 | >2.04 | ||
| No. of case subjects/control subjects | 31/85 | 30/86 | 25/87 | 4/21 | 8/22 | 9/23 | ||
| Crude OR (95% CI)* | 1 | 0.95 (0.53–1.72) | 0.79 (0.43–1.45) | >0.2 | 1 | 1.85 (0.52–6.62) | 1.89 (0.51–6.94) | >0.2 |
| Multivariable OR (95% CI)† | 1 | 1.08 (0.58–2.00) | 0.89 (0.47–1.68) | >0.2 | 1 | 2.60 (0.62–10.97) | 3.10 (0.71–13.54) | 0.15 |
| Multivariable OR (95% CI)‡ | 1 | 1.08 (0.58–2.03) | 0.91 (0.45–1.83) | >0.2 | 1 | 2.63 (0.60–11.41) | 2.20 (0.45–10.81) | >0.2 |
*Crude.
†Adjusted for smoking and alcohol drinking.
‡Additionally adjusted for BMI.