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A–L, Time course of HER2 tumor imaging in vivo: Mice bearing BT-474 (A–C), SKBR-3 (D–F), MCF-7 (G–I), or 9L (J–L) tumors were serially imaged after administration of HER2 probe at various time points. M, Graph shows mean tumor standard fluorescence values measured 6, 24, and 48 hours after HER2 probe administration. Error bars indicate standard error of the mean A (five tumors for each group). Significance of differences is shown: * = P < .05, ** = P < .005. F.U. = fluorescence units.
