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. Author manuscript; available in PMC: 2009 Dec 30.
Published in final edited form as: Eur J Neurosci. 2007 Sep 6;26(6):1670–1680. doi: 10.1111/j.1460-9568.2007.05747.x

Table 1.

Extracellular levels of DA, DOPAC and HVA (μM) measured in the striatum on the left side of intact and partially SNc-lesioned rats (DA PL) in basal conditions and after acute L-DOPA administration, before (L-DOPA effect), during (post L-DOPA + 1 h STN-HFS) and after (post L-DOPA + post STN-HFS) STN-HFS.

INTACT
 DA PL
Basal levels L-DOPA effect Post L-DOPA +STN HFS (t=1h) Post L-DOPA +STN HFS (t=2.5h) Basal levels L-DOPA effect Post L-DOPA +STN HFS (t=1h) Post L-DOPA +STN HFS (t=2.5h)
Dopamine
(μM) 		0.011 ± 0.0001 0.021 ± 0.0019
(+ 92% vs basal levels; p<0.001)		 0.0191 ±0.0017
(+ 74% vs basal levels; p<0.001)
(−9% vs L-DOPA effect; ns)		 0.0154 ± 0.0014
(+ 40% vs basal levels; p<0.05)
(− 52% vs L-DOPA effect; p<0.05)		 0.0124 ± 0.0018
(+12% vs Intact; ns)		 0.047 ± 0.0069
(+ 279% vs basal levels; p<0.001)		 0.0587 ± 0.0086
(+ 373% vs basal levels; p<0.001)
(+94% vs L-DOPA effect; ns)		 0.052 ± 0.0076
(+319% vs basal levels; p<0.05)
(+40% vs L-DOPA effect; ns)
DOPAC
(μM) 		1.7 ± 0.08 3.638 ± 0.17
(+ 114% vs basal levels; p<0.001)		 4.182 ± 0.19
(+ 146% vs basal levels; p<0.001)
(+15% vs L-DOPA effect; ns)		 3.383 ± 0.16
(+ 99% vs basal levels; p<0.001)
(−7% vs L-DOPA effect; ns)		 1.137 ± 0.097
(−33% vs Intact; p<0.001)		 3.821 ± 0.326
(+236% vs basal levels; p<0.001)		 5.732 ± 0.488
(+404% vs basal levels; p<0.001)
(+ 168% vs LDOPA effect; p<0.05)		 4.242 ± 0.361
(+273% vs basal levels; p<0.001)
(+11%vs L-DOPA effect; ns)
HVA
(μM) 		1.697 ± 0.085 2.885 ± 0.145
(+ 70% vs basal levels; p<0.001)		 3.292 ± 0.165
(+ 94% vs basal levels; p<0.001)
(+ 24% vs L-DOPA effect; p<0.001)		 3.767 ± 0.19
(+ 122% vs basal levels; p<0.001)
(+ 52% vs L-DOPA effect; p<0.001)		 1.145 ± 0.069
(−32.5% vs Intact; p<0.001)		 2.622 ± 0.158
(+ 129% vs basal levels; p<0.001)		 3.928 ± 0.237
(+ 243% vs basal levels; p<0.001)
(+ 114% vs LDOPA effect; p<0.001)		 4.328 ± 0.262
(+ 278% vs basal levels; p<0.001)
(+ 149% vs LDOPA effect; p<0.001)

The values presented for basal levels and L-DOPA effect periods are averages of the corresponding measures in intact rats, and in DA PL rats. Values corresponding to the “post L-DOPA+ 1 h STN HFS” and the “post L-DOPA+ post STN HFS (t=2.5 h)” periods correspond to values for intact rats subjected to STN-HFS in the part of the table headed “intact”, and DA PL rats subjected to STN-HFS in part of the table headed “DA PL”. The results are expressed as means ± SEM. ns: not significant.