TABLE 1.

Genes upregulated in the tick-passaged N40-75 isolate^a

Gene	Predicted function/gene product	Mean fold upregulationb in:
		B. burgdorferi N40-75-T	B. burgdorferi N40
bbk32	Fibronectin-binding protein	9.5	35.24
bbk17	Adenine deaminase	6.25	17.06
bbj09	Outer surface protein D (OspD)	5.19	4.32
bba66	Outer surface protein	4.97	26.85
bba25	Decorin-binding protein B (DbpB)	4.78	NC
bbk07	Putative lipoprotein	4.23	2.08
bba36	Lipoprotein	4.13	NC
bba07	Putative ChpAI protein	3.85	NC
bbk19	Putative lipoprotein	2.80	19.35
bbe31	Putative surface protein	2.60	41.82
bba04	S2 antigen	2.39	3.1
bbo39	ErpL protein	2.36	4.93
bbg01	Putative lipoprotein	2.35	NC
bbj23	Tetratricopeptide repeat domain protein	2.33	2.98
bbj24	Conserved hypothetical protein	1.95	7.65
bbg25	Borrelia Orf-D family	1.83	16.94
bbb19	Outer surface protein C (OspC)	1.79	NC
bba42	Conserved hypothetical protein	1.76	56.71
bba73	Putative antigen P35	1.65	NC
bbj34	Putative lipoprotein	1.56	9.84
bbk50	Putative immunogenic protein P37	1.48	3.63
bbk47	Conserved hypothetical protein	1.45	10.76
bbh37	Hypothetical protein	1.32	14.88
bba65	Putative lipoprotein	1.3	92.69
bbk45	Immunogenic protein P37	1.29	65.5
bb0365	Outer surface lipoprotein	1.1	NC

^aAs determined by microarray analyses. Results from two separate experiments were compared (P ≤ 0.05).

^bRelative to the expression of the gene in the original N40-75 isolate. NC, no change.