Skip to main content
. 2009 Oct 19;78(1):293–300. doi: 10.1128/IAI.00816-09

FIG. 1.

FIG. 1.

Differential cytokine production by monocytes stimulated with M. leprae or BCG. Human monocytes from healthy donors were stimulated with M. leprae (ML) or M. bovis BCG at a MOI of 5:1 (bacilli to monocyte) or left unstimulated (UN). Cell supernatants were collected at 24 and 48 h postinfection and analyzed by Luminex assay for the presence of cytokines. Results are shown for IL-1β, IL-18, IL-6, IL-10, and IL-12p40 at 48 h and for TNF-α at 24 h. Results for IL-1β, IL-6, IL-10, and TNF-α are the means ± standard error of 14 experiments (representing 14 independent donors) performed in duplicate. Results for IL-18 and IL-12p40 are the means ± standard error of 7 and 5 experiments, respectively (representing seven and five independent donors) performed in duplicate. A two-tailed paired t test was used for statistical analysis. Inset shows relative levels of NF-κB phospho-p65 S536 at 30 min postinfection (normalized to unstimulated cells) in M. leprae- or BCG-stimulated monocytes. A two-tailed paired t test was used for statistical analysis (*, P < 0.05, in comparison to BCG).