FIG. 3.

Association between SCGF variants and erythropoiesis. Plasma was obtained from children with acute malaria, and SCGF concentrations were determined by ELISA. (A) Correlation between SCGF concentrations and reticulocyte production index (RPI) levels in children with anemia (n = 70). Relationships between SCGF and RPI were determined by Spearman's correlation coefficient. (B) Association between SCGF −539C/T promoter variants and the RPI in anemic children. Data are shown for the CC (n = 14), CT (n = 29), and TT (n = 27) genotypes. Boxes represent the interquartile range, the line through the box is the median, and whiskers show 10th and 90th percentiles. Cross-group comparisons were determined by Kruskal-Wallis tests followed by Mann-Whitney U tests for pairwise comparison. The presence of the TT genotype was associated with significantly higher RPI relative to individuals with the CC genotype (P = 0.005).