TABLE 2.
Distribution of SCGF −539C/T promoter variants in children with malariaa
| Type of anemia | No. of participants | No. (%) of participants with SCGF −539C/T variant type |
P(C) | ||
|---|---|---|---|---|---|
| CC | CT | TT | |||
| Non-SMA | 302 | 76 (25.2) | 108 (35.8) | 118 (39.1) | 0.430 |
| SMA | 184 | 58 (31.5) | 71 (38.6) | 55 (29.9) | 0.508 |
| P | <0.001b | 0.259b | 0.025b | ||
a
Abbreviations: SMA, severe malarial anemia (Hb < 6.0 g/dl, with parasitemia of any density) (29); non-SMA, nonsevere malarial anemia (11.0 g/dl > Hb ≥ 6.0 g/dl, with parasitemia of any density); SCGF, stem cell growth factor; P(C), frequency of the wild-type allele in the population.
b
Statistical significance determined by chi-square analysis. There was a nonsignificant difference in the distribution of SCGF −539 genotypes between the two groups (P = 0.099).