TABLE 3.
Relationship between SCGF −539C/T promoter variants and susceptibility to SMAa
| Genotype | Result according to SMA definition |
|||||
|---|---|---|---|---|---|---|
| Hb < 6.0 g/dl |
Hb < 5.0 g/dl |
|||||
| OR | 95% CI | P | OR | 95% CI | P | |
| CC | 1.00 | 1.00 | ||||
| CT | 0.84 | 0.52-1.36 | 0.483 | 0.88 | 0.50-1.53 | 0.643 |
| TT | 0.57 | 0.34-0.94 | 0.027 | 0.51 | 0.33-0.95 | 0.030 |
a
Parasitemic children (n = 486) were categorized according to a modified definition of SMA based on age- and geographically matched Hb concentrations (i.e., Hb < 6.0 g/dl, with parasitemia of any density) (29) and the WHO definition of SMA (i.e., Hb < 5.0 g/dl, with parasitemia of any density). Odds ratios (OR) and 95% confidence intervals (95% CI) were determined using multivariate logistic regression controlling for age, gender, HIV-1 status, bacteremia, sickle cell trait (HbAS), G6PD deficiency, and α-thalassemia status.