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Deletion mapping of the Sup35-27p PFD. (A) Sequence of Sup35-27, with regions mutated in libraries 1 and 2 shown in bold italics. (B) Ten-amino-acid segments were deleted from the Sup35-27p PFD. Deletion mutants were expressed as the sole copy of SUP35 in the cell. All mutants produced stable curable prions. “+++” indicates that more than 4 Ade+ colonies per 106 cells were detected; “++” indicates 1 to 4 Ade+ colonies per 106 cells; “+” indicates fewer than 1 Ade+ colony per 106 cells.
