TABLE 2.
Urine chemistrya
| Measurement | Mouse type |
|
|---|---|---|
| Wild type | VAMP8 null | |
| Volume (ml) | 2.3 ± 0.2 | 5.4 ± 0.3 |
| Osmolality (mOsm) | 2,804 ± 51 | 1,526 ± 82 |
| Glucose (mg/dl) | 305 ± 57 | 152 ± 12 |
| Protein (mg/ml) | 1.27 ± 0.10 | 0.81 ± 0.06 |
| Creatinine (mM) | 4.2 ± 0.4 | 1.8 ± 0.4 |
| Chloride (mM) | 253 ± 11 | 120 ± 5 |
| Sodium (mM) | 215 ± 32 | 81 ± 13 |
| Potassium (mM) | 291 ± 15 | 139 ± 9 |
| Calcium (mM) | 2.3 ± 0.9 | 0.9 ± 0.3 |
a
Urine was collected for 24 h from groups of six 3-month-old female mice. Data shown are means ± standard errors of the means. A total of six groups of mice of each genotype were used. P < 0.01 for all the parameters analyzed.