TABLE 1.

Cancers and cancer cell lines with genetic or epigenetic modifications in the CHFR gene

Tissue and/or cell type	Mutation	Reference(s)
Lung cancer tissue and cell lines	Genetic mutation, hypermethylation leading to downregulation of CHFR expression	23, 77
Esophageal primary cancer and cell lines	Hypermethylation	78, 110
Gastric cancer and cell lines	Hypermethylation	51, 52, 60, 78
Brain tumors	Hypermethylation	23
Bone tumors	Hypermethylation	23
Colorectal cancers and adenomas	Hypermethylation	23, 127
Head and neck cancers	Hypermethylation	127
Breast cancer cells	Hypermethylation	30
Gallbladder carcinomas	Hypermethylation	119
T-cell lymphoma	Hypermethylation	132
Nasopharyngeal carcinomas	Hypermethylation	21
Hepatocellular carcinoma	Hypermethylation	108
Malignant peripheral nerve sheath tumors	Reduced expression	64
Endometrial cancer	Hypermethylation	139