TABLE 5.

Significance (Fisher's exact test) of associations between HLA-B*4001 (subjects N1 to N10) and HLA-B*5602 (subjects N11 to N17) genotypes and the number of HBeAg-negative subjects with at least one clone containing a nonsynonymous mutation at amino acid sites known to exhibit positive selection

Site	No. of subjects				P
	HLA-B* 4001/4001		HLA-B* 5602/5602
	NSa present	NS absent	NS present	NS absent
S 21	2	8	6	1	0.02
E 77	7	3	1	6	0.05
E 113	8	2	0	7	0.002

^aNS, nonsynonymous mutations.