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Transient testing of selected mutations
| Compound | Fold resistance relative to wild typea |
|||
|---|---|---|---|---|
| Wild type | L31V | Q54L | L31V/Q54L | |
| BMS-824 | 1 | 60 | 9 | 354 |
| BMS-858 | 1 | 18 | 7 | 100 |
| PI | 1 | 2 | 2 | 2 |
The relative change in resistance is determined by dividing the EC50 obtained with mutant HCV replicons by the EC50 obtained with the wild-type replicon.
