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. 2009 Oct 21;84(1):585–598. doi: 10.1128/JVI.01748-09

FIG. 2.

FIG. 2.

IRF3 activation and STAT1-dependent signaling contribute to UV-HCMV-induced upregulation of ZBP1 mRNA. (A) Change as determined by qPCR of ZBP1 mRNA in THFs exposed to UV-HCMV relative to that in unexposed cells following transfection of NS or IRF3-directed siRNA. (B) Change of ZBP1 mRNA relative to untreated cells in THFs and THF-STAT1-DN cells treated with IFN-β (100 U/ml) or UV-HCMV in the presence and absence of CHX (200 μg/ml; untreated control cells were also treated with CHX). The values are the changes in treated relative to untreated cells normalized to the change observed in IFN-β-treated THFs (set to 1).