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Proposed model of HCMV-triggered, IRF3-dependent transcriptional induction and ZBP1 expression. The schematic shows HCMV-triggered IRF3 activation and HCMV-mediated induction of ZBP1 expression in human fibroblasts. The dashed arrows indicate de novo transcription or translation, and the solid arrows indicate molecular interaction or signal transduction (e.g., phosphorylation).
