TABLE 1.
IC50s for CD4-scFv reagents
| Env | Clade | IC50 (nM)a |
|||||
|---|---|---|---|---|---|---|---|
| CD4-scFv17b | CD4-scFvm9 | CD4-scFv21c | CD4-scFvE51 | CD4 | scFvE51 | ||
| SF162.LS | B | 3.5 | 1.7 | 1.40 | 0.75 | 16 | 15 |
| SC422661.8 | B | 91 | ND | 1200 | 24 | 480 | 61 |
| TRJO4551.58 | B | 1000 | 720 | 1500 | 500 | 940* | 320 |
| QH0692.42 | B | 59 | ND | ND | 31 | 110 | 450 |
| RHPA4259.7 | B | 110 | ND | 370 | 48 | 170 | 76 |
| ZM53M.PB12 | C | 200 | 150 | 880 | 60 | 390* | 66 |
| ZM214M.PL15 | C | 91 | 110 | 330 | 23 | 480 | 120 |
| Du172.17 | C | 24 | 66 | 89 | 26 | 150 | 190 |
| Geometric mean | 70 | 66 | 220 | 29 | 210 | 110 | |
| Arithmetic mean | 200 | 210 | 620 | 89 | 340 | 160 | |
a
Results are from in-house neutralization assays except for values marked with an asterisk, which are from CAVD core neutralization facility assays. ND, not determined.