TABLE 5.
IC50s for CD4HC-IgG2G12, 2G12, and CD4-CD4i reagents in the presence and absence of 3% fructose
| Env | Effect on IC50 of fructosea |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| CD4HC-IgG2G12 monomer |
2G12 monomer |
CD4HC-(GS7)-IgGE51 |
|||||||
| IC50 (nM) |
Fold change | IC50 (nM) |
Fold change | IC50 (nM) |
Fold change | ||||
| + | − | + | − | + | − | ||||
| WITO4160.33 | 200 | 18 | 11 | 650 | 65 | 10 | 110 | 91 | 1.2 |
| SC422661.8 | 430 | 46 | 9.3 | 260 | 64 | 4.1 | 310 | 300 | 1.0 |
| QH0692.42 | 16 | 6 | 2.7 | 130 | 44 | 3.0 | 18 | 27 | 0.7 |
| TRO.11 | 28 | 5.7 | 4.9 | 33 | 5.3 | 6.2 | ND | ND | ND |
+, treatment with 3% fructose; −, no fructose; ND, not determined.