FIG. 6.

Lower frequencies of CD57^hi T cells in CSF than in blood of HIV-positive patients. (A) Representative histograms of CD57 expression on CD4⁺, CD8⁺, HIV-specific CD8⁺, and CMV-specific CD8⁺ T cells in blood and CSF of HIV-positive patients. Gates representing CD57^hi, CD57^int, and CD57^lo T cells were defined by gating on CD8⁺ T cells in blood. (B to E) Relationships between frequencies of CD57^hi T cells in CSF and blood of HIV-positive patients. Data from 15 HIV-positive patients are shown. On plots for CD4⁺ and CD8⁺ T cells, each data point represents an individual participant. On plots for HIV-specific CD8⁺ and CMV-specific CD8⁺ T cells, each data point represents an individual tetramer response for each participant studied. The diagonal dashed line represents the line of unity. P values were derived from a two-tailed Wilcoxon signed-rank t test.