TABLE 3.
Distribution and corresponding carbapenem MIC ranges for strains with different resistance determinants
| Resistance determinant profile | No. of isolates | MIC (μg/ml) range |
||
|---|---|---|---|---|
| Imipenem | Meropenem | Ertapenem | ||
| IMP-4+, no porin loss or decreased expression | 4 | 2-4 | 4 | 2-4 |
| IMP-4+, single porin loss | 3 | 8 | 8 | 32 |
| IMP-4+, double porin loss | 1 | 16 | 8 | 32 |
| KPC-2+, single porin loss or decreased expression | 5 | 8-16 | 4-16 | 8-32 |
| KPC-2+, double porin loss | 1 | >256 | 256 | >256 |
| IMP-8+, double porin loss | 2 | 8 | 2 | 4-8 |
| Carbapenemase−, ESBL+, AmpC−, single porin loss or decreased expression | 2 | 1-2 | 1-2 | 4-8 |
| Carbapenemase−, ESBL+, AmpC−, double porin loss | 11 | 2-32 | 4-16 | 16-128 |
| Carbapenemase−, ESBL−, AmpC+, single porin loss | 1 | 8 | 4 | 8 |
| Carbapenemase−, ESBL−, AmpC+, double porin loss or decreased expression | 5 | 4-32 | 2-16 | 16-64 |
| Carbapenemase−, ESBL+, AmpC+, double porin loss or decreased expression | 12 | 4-32 | 2-16 | 32-128 |
| Carbapenemase−, ESBL−, AmpC−, single porin loss | 1 | 4 | 0.125 | 0.064 |
| Carbapenemase−, ESBL−, AmpC−, double porin loss or decreased expression | 1 | 4 | 4 | 32 |