TABLE 1.
Baseline characteristics of the study participants by pregnancy status and treatment allocation
| Parameter | Valuea |
|||
|---|---|---|---|---|
| Pregnant |
Nonpregnant |
|||
| AZI-CQ (n = 15) | AZI-SP (n = 14) | AZI-CQ (n = 14) | AZI-SP (n = 15) | |
| Age (yr) | 26.9 ± 4.1 | 23.9 ± 5.1 | 25.7 ± 5.8 | 27 ± 6.5 |
| Wt (kg) | 53.5 ± 7.1b | 56.4 ± 7.9a | 51.4 ± 5.4 | 51.9 ± 4.9 |
| Height (cm) | 154 ± 7.4 | 154 ± 7.3 | 154 ± 6.4 | 154 ± 2.8 |
| Axillary temp (°C) | 36.4 ± 0.7 | 36.5 ± 0.6 | 36.7 ± 0.3 | 36.4 ± 0.3 |
| P. falciparum parasitemia | 3 (20) | 3 (21) | 1 (7) | 0 (0) |
| P. vivax parasitemia | 1 (7) | 0 (0) | 0 (0) | 1 (7) |
| Gestational age (wk) | 24 [22-27] | 21 [19-24] | ||
| Gravidity | 3 [2-5] | 2 [1-4] | 1 [0-3] | 2 [0-3] |
| Parity | 2 [1-4] | 1 [0-2] | 0 [0-3] | 1 [0-3] |
| Respiratory rate (/min) | 20 ± 1 | 22 ± 5 | 20 ± 2 | 20 ± 1 |
| Supine pulse rate (/min) | 91 ± 10 | 89 ± 7 | 82 ± 10 | 88 ± 7 |
| Supine MAP (mm Hg)c | 78 ± 7 | 81 ± 10 | 79 ± 9 | 82 ± 7 |
| Hemoglobin (g/dl) | 8.5 ± 1.6b | 8.2 ± 1.2b | 9.3 ± 1.9 | 10 ± 1.3 |
| Blood glucose (mmol/liter) | 5.9 ± 1.6 | 5.7 ± 0.8 | 6.2 ± 1.1 | 5.6 ± 2.7 |
a
Data are mean ± SD, median [IQR], or number (%).
b
P < 0.05 versus nonpregnant subjects.
c
Mean arterial pressure, calculated by adding 1/3 of the pulse pressure (systolic minus diastolic pressure) to the diastolic pressure.