TABLE 3.
Model building, final parameter estimates, and bootstrap results from the AZI population pharmacokinetic modeling
| Parametera | Value |
||
|---|---|---|---|
| Base model | Final covariate model | Bootstrap (n = 1,000) (median [95% CI]) | |
| OFV | 7,999.870 | 7,993.646 | 7,974.699 [7,756.673-8,201.238] |
| Pharmacokinetic (estimate [% RSE]) | |||
| DUR (h) | 1.66 [10.4] | 1.55 [3.3] | 1.56 [1.21-2.01] |
| ka (h−1) | 0.513 [3.2] | 0.525 [14.8] | 0.524 [0.451-0.623] |
| VC/F (liters) | 504 [13.9] | 384 [17.6] | 371 [235-554] |
| Pregnancy on VC/F (liters) | 330 [69.4] | 318 [48-604] | |
| CL/F (liters h−1) | 158 [3.9] | 158 [6.7] | 158 [145-171] |
| VP1/F (liters) | 4,080 [8.6] | 4,080 [12.5] | 4,045 [3,402-4,870] |
| Q1/F (liters h−1) | 327 [5.7] | 325 [12.7] | 326 [288-368] |
| VP2/F (liters) | 5,070 [5.6] | 5,040 [7.3] | 5,070 [4,262-5,730] |
| Q2/F (liters h−1) | 67.2 [11.5] | 66.4 [12.4] | 67.5 [48.5-84.0] |
| Random (CV % [% RSE]) | |||
| BSV Vc/F | 111.4 [20.9] | 99.6 [35.5] | 99.0 [72.6-127.6] |
| BSV CL/F | 28.3 [24.1] | 28.3 [33.1] | 27.9 [21.6-34.5] |
| BSV VP1/F | 35.8 [27.0] | 35.6 [27.2] | 34.8 [25.7-45.2] |
| BSV DUR | 73.0 [21.4] | 76.9 [22] | 75.5 [55.4-95.6] |
| RUV | |||
| Proportional error (CV % [% RSE]) | 31.3 [9.5] | 31.2 [15.1] | 30.9 [28.1-33.8] |
a
CV, coefficient of variation.