TABLE 4.
Secondary pharmacokinetic parameters derived from post hoc Bayesian estimates for pregnant and nonpregnant study participants (median [IQR])
| Parameter | Value |
||
|---|---|---|---|
| Pregnant (n = 31) | Nonpregnant (n = 29) | P value | |
| DUR (h) | 1.65 [0.94-2.34] | 1.75 [1.02-2.38] | NSa |
| ka (h−1) | 0.525 [0.525-0.525] | 0.525 [0.525-0.525] | NS |
| VC/F (liters) | 647 [422-995] | 249 [157-363] | <0.001 |
| VP1/F (liters) | 3,620 [2,747-3,951] | 2,909 [2,296-3,586] | NS |
| VP2/F (liters) | 3,888 [3,708-4,104] | 3,672 [3,456-3,888] | 0.034 |
| VSS/F (liters) | 8,355 [7,460-8,973] | 6,875 [6,115-7,526] | 0.002 |
| it1/2αb (h) | 0.88 [0.57-1.36] | 0.39 [0.24-0.56] | <0.001 |
| t1/2βb (h) | 20.7 [18.3-22.8] | 18.8 [15.3-21] | NS |
| t1/2γb (h) | 78.2 [74-82.5] | 77.1 [71.5-84.5] | NS |
| AUC0-∞ (μg h liter−1) | 28,713 [25,913-32,942] | 31,781 [28,736-38,012] | NS |
a
NS, not significant.
b
t1/2α, t1/2β, and t1/2γ are the first-distribution, second-distribution, and terminal elimination half-lives respectively.