TABLE 3.
Drug and type of straina | MIC (μg/ml)b |
||
---|---|---|---|
Range (μg/ml) | 50% | 90% | |
CEM-101 | 0.008-1 | 0.06 | 0.5 |
Macrolide S | 0.008-0.03 | 0.015 | 0.03 |
erm(B) | 0.03-1 | 0.5 | 1 |
mef(A) | 0.06-0.25 | 0.125 | 0.25 |
erm(A) | 0.016-0.5 | 0.03 | 0.125 |
L4 mutations | 0.06 | ||
Erythromycin | 0.03->64 | 16 | >64 |
Macrolide S | 0.03-0.25 | 0.06 | 0.125 |
erm(B) | >64->64 | >64 | >64 |
mef(A) | 8-32 | 16 | 32 |
erm(A) | 2->64 | 4 | >64 |
L4 mutations | 2 | ||
Azithromycin | 0.06->64 | 8 | >64 |
Macrolide S | 0.06-0.25 | 0.125 | 0.25 |
erm(B) | >64->64 | >64 | >64 |
mef(A) | 0.5-16 | 8 | 8 |
erm(A) | 2->64 | 16 | >64 |
L4 mutations | 2 | ||
Clarithromycin | 0.015->64 | 4 | >64 |
Macrolide S | 0.015-0.06 | 0.03 | 0.06 |
erm(B) | 32->64 | >64 | >64 |
mef(A) | 0.5-8 | 4 | 8 |
erm(A) | 0.25->64 | 2 | >64 |
L4 mutations | 1 | ||
Telithromycin | 0.03-16 | 0.125 | 8 |
Macrolide S | 0.03-0.06 | 0.06 | 0.06 |
erm(B) | 0.03-16 | 8 | 16 |
mef(A) | 0.125-1 | 0.5 | 1 |
erm(A) | 0.03-0.25 | 0.06 | 0.125 |
L4 mutations | 0.06 | ||
Amoxicillin-clavulanate | <0.015-0.125 | 0.03 | 0.03 |
Macrolide S | 0.015-0.03 | 0.03 | 0.03 |
erm(B) | <0.015-0.125 | <0.015 | 0.03 |
mef(A) | <0.015-0.125 | 0.015 | 0.06 |
erm(A) | <0.015-0.03 | 0.03 | 0.03 |
L4 mutations | 0.03 | ||
Levofloxacin | 0.5-2 | 0.5 | 1 |
Macrolide S | 0.5-1 | 0.5 | 0.5 |
erm(B) | 0.5-1 | 0.5 | 1 |
mef(A) | 0.5-2 | 0.5 | 1 |
erm(A) | 0.5-2 | 0.5 | 1 |
L4 mutations | 0.5 | ||
Moxifloxacin | 0.0125-0.5 | 0.25 | 0.25 |
Macrolide S | 0.125-0.25 | 0.25 | 0.25 |
erm(B) | 0.125-0.25 | 0.25 | 0.25 |
mef(A) | 0.25-0.5 | 0.25 | 0.25 |
erm(A) | 0.125-0.5 | 0.25 | 0.25 |
L4 mutations | 0.25 | ||
Penicillin G | <0.008-0.125 | 0.015 | 0.015 |
Macrolide S | 0.008-0.015 | 0.015 | 0.015 |
erm(B) | <0.008-0.125 | 0.015 | 0.015 |
mef(A) | <0.008-0.125 | 0.015 | 0.03 |
erm(A) | <0.008-0.015 | 0.015 | 0.015 |
L4 mutations | 0.015 | ||
Clindamycin | 0.03->64 | 0.125 | >64 |
Macrolide S | 0.03-0.125 | 0.06 | 0.06 |
erm(B) | 0.06->64 | >64 | >64 |
mef(A) | 0.03-0.125 | 0.06 | 0.125 |
erm(A) | 0.06-0.5 | 0.125 | 0.25 |
L4 mutations | 0.06 |
S, susceptible. A total of 26 macrolide-susceptible, 19 erm(B), 38 mef(A), and 40 erm(A) strains, as well as 1 strain with L4 mutations, were tested.
50 and 90%, MICs at which 50% and 90% of isolates, respectively, are inhibited.