TABLE 4.
MIC50s and MIC90sa of group A streptococcal strains with defined macrolide-resistant mechanisms
| Drug | MIC (μg/ml) for strains with the following macrolide-resistant mechanism (no. of strains): |
|||||
|---|---|---|---|---|---|---|
|
erm(B) (19) |
mef(A) (38) |
erm(A) (40) |
||||
| MIC50 | MIC90 | MIC50 | MIC90 | MIC50 | MIC90 | |
| CEM-101 | 0.5 | 1 | 0.125 | 0.25 | 0.03 | 0.125 |
| Erythromycin | >64 | >64 | 16 | 32 | 4 | >64 |
| Azithromycin | >64 | >64 | 8 | 8 | 16 | >64 |
| Clarithromycin | >64 | >64 | 4 | 8 | 2 | >64 |
| Telithromycin | 8 | 16 | 0.5 | 1 | 0.06 | 0.125 |
| Clindamycin | >64 | >64 | 0.06 | 0.125 | 0.125 | 0.25 |
| Amoxicillin-clavulanate | <0.015 | 0.03 | 0.015 | 0.06 | 0.03 | 0.03 |
| Levofloxacin | 0.5 | 1 | 0.5 | 1 | 0.5 | 1 |
| Moxifloxacin | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 |
| Penicillin G | 0.015 | 0.015 | 0.015 | 0.03 | 0.015 | 0.015 |
a
MIC50 and MIC90, MICs at which 50% and 90% of isolates, respectively, are inhibited.