TABLE 3.
Summary of selected plasma S/GSK1349572 pharmacokinetic parameters following single-dose administration
| Treatment (mg of S/GSK1349572) | No. of subjects | PK parametera |
||||||
|---|---|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Tmax (h)b | AUC0-t (μg·h/ml) | AUC0-∞ (μg·h/ml) | CL/F (liters/h) | t1/2 (h) | C24 (μg/ml) | ||
| 2 | 8 | 0.231 (20) | 0.63 (0.25-1.00) | 2.63 (28) | 2.78 (26) | 0.72 (26) | 12.7 (20) | 0.0382 (41) |
| 5 | 7 | 0.661 (20) | 0.50 (0.50-1.50) | 8.54 (25) | 8.87 (27) | 0.56 (27) | 14.3 (25) | 0.126 (28) |
| 10 | 8 | 1.23 (9) | 0.63 (0.25-1.50) | 14.3 (21) | 14.6 (21) | 0.69 (22) | 12.7 (9) | 0.196 (34) |
| 25 | 8 | 2.76 (12) | 0.75 (0.50-1.50) | 34.3 (28) | 35.1 (30) | 0.71 (30) | 12.7 (21) | 0.469 (41) |
| 50 | 6 | 4.56 (21) | 1.25 (0.50-3.00) | 70.8 (19) | 73.2 (19) | 0.68 (19) | 14.2 (19) | 1.06 (27) |
| 100 | 5 | 8.14 (12) | 1.00 (0.75-3.00) | 131 (22) | 136 (24) | 0.74 (24) | 14.7 (23) | 1.80 (33) |
a
Values are geometric means (with CVs, expressed as percentages, given in parentheses), except for Tmax.
b
Values are medians (ranges).