TABLE 4.
Summary of selected plasma S/GSK1349572 pharmacokinetic parameters following day 10 dose administration
| S/GSK1349572 treatment | No. of subjects | PK parametera |
||||
|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Tmaxb (h) | AUC0-τ (μg·h/ml) | Cmin (μg/ml) | Cτ (μg/ml) | ||
| 10 mg once a day | 8 | 1.47 (24) | 0.50 (0.25-2.00) | 16.7(15) | 0.27 (25) | 0.35 (20) |
| 25 mg once a day | 10 | 3.09 (26) | 1.00 (0.50-2.00) | 38.4 (23) | 0.66 (32) | 0.84 (33) |
| 50 mg once a day | 8 | 6.16 (15) | 1.00 (0.50-2.00) | 76.8 (19) | 1.48 (25) | 1.64 (25) |
a
Values are geometric means (with CVs, expressed as percentages, given in parentheses), except for Tmax.
b
Values are medians (ranges).