TABLE 4.
MICs and embB genotypes of M. tuberculosis strain 210 and its isogenic mutants constructed by allelic exchange methods
| M. tuberculosis strain | MIC (μg/ml) |
embB genotypea | ||
|---|---|---|---|---|
| EMB | INH | RIF | ||
| 210 | 2 | 0.05 | 0.05 | Wild type |
| NJT210CGG | 12 | 0.05 | 0.05 | embB497 CAG-CGG (Gln-Arg) |
| NJT210CGG-CAG | 2 | 0.05 | 0.05 | Wild type |
| NJT210GCC | 7 | 0.05 | 0.05 | embB406 GGC-GCC (Gly-Ala) |
| NJT210GAC | 7 | 0.05 | 0.05 | embB406 GGC-GAC (Gly-Asp) |
| NJT210TGC | 7 | 0.05 | 0.05 | embB406 GGC-TGC (Gly-Cys) |
| NJT210TCC | 6 | 0.05 | 0.05 | embB406 GGC-TCC (Gly-Ser) |
a
The remaining sequence of the embB gene was identical in all strains.