TABLE 1.
In vitro susceptibilities of ocular Fusarium isolates to thimerosal, amphotericin B, and natamycin
| Organism (no. of isolates) and antifungal agent | MIC range (mode)b | MIC50 | MIC90 |
|---|---|---|---|
| Fusarium solani species complex (82) | |||
| Thimerosal | 0.0078-0.0313 (0.0156) | 0.0156 | 0.0313 |
| Amphotericin B | 0.5-16 (1) | 1 | 2 |
| Natamycin | 4-32 (4) | 4 | 8 |
| Fusarium moniliforme species complex (20) | |||
| Thimerosal | 0.0156-0.0313 (0.0156) | 0.0156 | 0.0313 |
| Amphotericin B | 1-8 (2) | 2 | 2 |
| Natamycin | 4-8 (4) | 4 | 8 |
| Fusarium avenaceum species complex (16) | |||
| Thimerosal | 0.0156-0.0313 (0.0156) | 0.0156 | 0.0313 |
| Amphotericin B | 0.5-8 (2) | 2 | 4 |
| Natamycin | 4-32 (8) | 8 | 8 |
| Other Fusarium isolates (18)a | |||
| Thimerosal | 0.0078-0.0625 (0.0156) | 0.0156 | 0.0313 |
| Amphotericin B | 0.5-2 (1) | 1 | 2 |
| Natamycin | 4-8 (4) | 4 | 8 |
| Fusarium spp. (136) | |||
| Thimerosal | 0.0078-0.0625 (0.0156) | 0.0156 | 0.0313 |
| Amphotericin B | 0.5-16 (1) | 1 | 2 |
| Natamycin | 4-32 (4) | 4 | 8 |
a
Includes 9 strains of Fusarium oxysporum species complex, 5 strains of Fusarium poae species complex, and 4 strains of Fusarium lateritium species complex.
b
Values are in micrograms per milliliter.