TABLE 2.

In vitro susceptibilities of ocular Aspergillus and Alternaria alternata isolates to thimerosal, amphotericin B, and natamycin

Organism (no. of isolates) and antifungal agent	MIC range (mode)b	MIC50	MIC90
Aspergillus flavus species complex (49)
Thimerosal	0.0313-0.0625 (0.0625)	0.0625	0.0625
Amphotericin B	1-32 (2)	2	2
Natamycin	8-32 (32)	32	32
Aspergillus fumigatus species complex (11)
Thimerosal	0.0156-0.0625 (0.0313)	0.0313	0.0625
Amphotericin B	0.5-4 (1)	1	2
Natamycin	4-32 (4)	4	4
Aspergillus oryzae species complex (12)
Thimerosal	0.0156-0.0625 (0.0625)	0.0625	0.0625
Amphotericin B	1-2 (1)	1	2
Natamycin	4-32 (32)	32	32
Aspergillus versicolor species complex (12)
Thimerosal	0.0078-0.0625 (0.0078)	0.0156	0.0625
Amphotericin B	0.5-2 (1)	1	2
Natamycin	4-32 (8)	8	32
Other Aspergillus isolates (14)a
Thimerosal	0.0078-0.0625 (0.0156)	0.0156	0.0313
Amphotericin B	0.125-2 (1)	1	2
Natamycin	0.25-32 (4)	4	32
Aspergillus spp. (98)
Thimerosal	0.0078-0.0625 (0.0625)	0.0625	0.0625
Amphotericin B	0.125-32 (1)	1	2
Natamycin	0.25-32 (32)	32	32
Alternaria alternata (10)
Thimerosal	0.0078-0.0625 (0.0156)	0.0156	0.0313
Amphotericin B	0.0625-2 (0.125)	0.125	1
Natamycin	2-8 (4)	4	4

^aIncludes 8 strains of Aspergillus niger species complex, 2 strains of Aspergillus candidus, 2 strains of Aspergillus nidulans, 1 strain of Aspergillus ochraceus, and 1 strain of Aspergillus wentii.

^bValues are in micrograms per milliliter.