FIG. 4.

Compared with genotype 1b (Con1) replicons, genotype 2a (JFH-1) replicons were more resistant to both compound 6 and IFN-α-2a. Genotype 1b (Con1) replicon cells (Huh-luc/neo-ET) and genotype 2a (JFH-1) replicon cells (YSGR-JFH) were incubated with increasing concentrations of compound 6 (A) or IFN-α-2a (B). Cells were harvested 72 h after incubation. The HCV RNA level was quantitated by qRT-PCR and expressed as a percentage of the level for mock-treated controls (mean ± SD of results from three independent experiments).