TABLE 2.
MICs obtained using the EUCAST EDef 7.1 (RPMI-2G and 50% inhibition)a
| Drug and species | MIC (μg/ml) |
NG | Total | Distance | Overlap | WT-UL (S ≤ X) | VMEs | MEs | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.008 | 0.015 | 0.032 | 0.064 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | >8 | ||||||||
| Anidulafungin | |||||||||||||||||||
| C. albicans (R) | 2 | 2 | 2 | 2 | 2 | 10 | |||||||||||||
| C. albicans (S) | 10 | 10 | 3 | 0.015 | |||||||||||||||
| C. dubliniensis (R) | 1 | 1 | |||||||||||||||||
| C. dubliniensis (S) | 1 | 1 | 6 | 0.015 | |||||||||||||||
| C. glabrata (R) | 2 | 3 | 1 | 2 | 2 | 1 | 11 | ||||||||||||
| C. glabrata (S) | 1 | 4 | 4 | 9 | 2 | 0.064 | |||||||||||||
| C. krusei (R) | 1 | 1 | 1 | 3 | 1/3 | 1/3 | |||||||||||||
| C. krusei (S) | 12 | 1 | 13 | −1 | 0.125 | ||||||||||||||
| C. parapsilosis (S) | 5 | 7 | 5 | 1 | 1 | 19 | 4 | 1/19 | |||||||||||
| C. tropicalis (R) | 1 | 1 | 2 | 4 | |||||||||||||||
| C. tropicalis (S) | 2 | 10 | 2 | 1 | 15 | 1 | 0.064 | ||||||||||||
| Caspofungin | |||||||||||||||||||
| C. albicans (R) | 6 | 4 | 10 | 6/10 | |||||||||||||||
| C. albicans (S) | 1 | 9 | 10 | 2 | 2 | ||||||||||||||
| C. dubliniensis (R) | 1 | 1 | |||||||||||||||||
| C. dubliniensis (S) | 1 | 1 | 3 | 2 | |||||||||||||||
| C. glabrata (R) | 1 | 5 | 2 | 2 | 1 | 11 | 6/10 | ||||||||||||
| C. glabrata (S) | 9 | 9 | 1 | 2 | |||||||||||||||
| C. krusei (R) | 1 | 1 | 1 | 3 | 1/3 | ||||||||||||||
| C. krusei (S) | 13 | 13 | 1 | 4 | |||||||||||||||
| C. parapsilosis (S) | 2 | 14 | 3 | 19 | 8 | ||||||||||||||
| C. tropicalis (R) | 1 | 3 | 4 | 1/4 | |||||||||||||||
| C. tropicalis (S) | 11 | 4 | 15 | 1 | 2 | ||||||||||||||
| Micafungin | |||||||||||||||||||
| C. albicans (R) | 1 | 1 | 2 | 5 | 1 | 10 | 1/10 | ||||||||||||
| C. albicans (S) | 4 | 6 | 10 | 2 | 0.064 | ||||||||||||||
| C. dubliniensis (R) | 1 | 1 | |||||||||||||||||
| C. dubliniensis (S) | 1 | 1 | 5 | 0.125 | |||||||||||||||
| C. glabrata (R) | 1 | 2 | 5 | 2 | 1 | 11 | 1/10 | 8/10 | |||||||||||
| C. glabrata (S) | 4 | 5 | 9 | −1 | 0.125 | ||||||||||||||
| C. krusei (R) | 1 | 1 | 1 | 3 | |||||||||||||||
| C. krusei (S) | 12 | 1 | 13 | 2 | 0.5 | ||||||||||||||
| C. parapsilosis (S) | 5 | 10 | 4 | 19 | 4 | ||||||||||||||
| C. tropicalis (R) | 1 | 1 | 2 | 4 | 1/4 | ||||||||||||||
| C. tropicalis (S) | 12 | 3 | 15 | 1 | 0.125 | ||||||||||||||
a
NG, no growth; distance, number of twofold steps between wild-type (S) and fks hot spot mutant (R) populations; overlap, number of fks R isolates overlapping with the S population/total number of isolates in the group; WT-UL, wild type cut off (for calculation, see Materials and Methods); VMEs, R isolates misclassified as susceptible using the WT-UL as the breakpoint for susceptibility; MEs, S isolates misclassified as resistant. Only isolates with mutations in the hot spot regions were regarded as resistant isolates.