TABLE 2.
Mean (standard deviation) PK parameters of nemonoxacin after ascending single dosing
| Dose (mg) | AUC0-∞ (h·μg/ml) | Cmax (μg/ml) | Tmax (h) | t1/2 (h) | Vz/F (liters/kg) | CLo (liters/h/kg) | CLr (liters/h/kg) | Ae (%) |
|---|---|---|---|---|---|---|---|---|
| 25 | 1.19 (0.19) | 0.15 (0.05) | 0.92 (0.49) | 9.71 (1.50) | 4.21 (0.62) | 0.30 (0.050) | 0.18 (0.060) | 56.24 (15.84) |
| 50 | 2.99 (0.18) | 0.37 (0.045) | 1.08 (0.20) | 8.49 (1.31) | 2.78 (0.27) | 0.23 (0.035) | 0.12 (0.049) | 51.11 (17.06) |
| 125 | 7.67 (1.46) | 1.22 (0.31) | 0.75 (0.27) | 11.13 (4.09) | 3.38 (0.87) | 0.22 (0.046) | 0.080 (0.029) | 38.28 (15.66) |
| 250 | 15.45 (3.94) | 2.40 (0.66) | 0.92 (0.20) | 10.86 (3.91) | 3.58 (0.89) | 0.24 (0.056) | 0.11 (0.055) | 44.85 (17.48) |
| 500 | 32.36 (3.01) | 3.41 (0.58) | 2.0 (0.87) | 14.75 (3.06) | 4.25 (1.31) | 0.20 (0.024) | 0.068 (0.021) | 34.15 (9.05) |
| 1,000 | 63.31 (10.01) | 7.22 (0.88) | 1.67 (0.26) | 16.41 (2.54) | 5.28 (0.78) | 0.22 (0.025) | 0.084 (0.031) | 36.54 (12.03) |
| 1,500 | 117.84 (10.74) | 12.1 (1.70) | 2.67 (0.68) | 13.04 (1.51) | 3.42 (0.42) | 0.18 (0.025) | 0.069 (0.0077) | 37.58 (1.99) |