TABLE 1.

Prevalence of pfdhfr and pfdhps genotypes by treatment arm and treatment outcome in Rukara

pfdhfr mutant	pfdhps mutant	CPG-DDS+A			AQ+SP
		ACPR group	TTF group	Cure rate (%)	ACPR group	TTF group	Cure rate (%)
Wild type	Double	0	0		1	0	100
Double	Double	2	0	100	2	1	66.7
	Triple	0	0		1	2	33.3
	Mixed	0	0		0	1	0
	All double	2	0	100	3	4	42.3
Triple	Wild type/single	4	2	66.7	2	0	100
	Double	47	14a	77.0	23	34	40.4
	Triple	54	26	67.5	31	64	32.6
	Mixed	6	1	85.7	6	2	75.0
	All triple	111	43	72.0	62	100	38.2
Quadruple	Double	3	4	42.9	2	3	40.0
	Triple	7	7	50.0	1	13	7.1
	Mixed	2	1	66.7	0	0
	All quadruple	12	12	50.0	3	16	15.8
Mixed	Triple	5	1	83.3	1	0	100
	Mixed	1	0	100	0	0
	All mixed	6	1	85.7	1	0	100
Total		131	56		70	120

^aOne patient in this group received a blood transfusion.