TABLE 2.
Prevalence of pfdhfr and pfdhps genotypes by treatment arm and treatment outcome in Mashesha
| pfdhfr mutant | pfdhps mutant | CPG-DDS+A |
AQ+SP |
||||
|---|---|---|---|---|---|---|---|
| ACPR group | TTF group | Cure rate (%) | ACPR group | TTF group | Cure rate (%) | ||
| Double | Wild type/single | 9 | 1a | 90.0 | 14 | 0 | 100.0 |
| Double | 34 | 11a | 75.6 | 22 | 4a | 84.6 | |
| Triple | 14 | 5 | 73.7 | 13 | 0 | 100.0 | |
| Mixed | 8 | 1 | 88.9 | 9 | 2 | 81.8 | |
| All double | 65 | 18 | 78.3 | 58 | 6 | 90.6 | |
| Triple | Wild type/single | 6 | 4 | 60.0 | 10 | 1 | 90.9 |
| Double | 26 | 14 | 65.0 | 34 | 6 | 85.0 | |
| Triple | 11 | 7 | 61.1 | 25 | 6 | 80.6 | |
| Mixed | 5 | 3 | 62.5 | 12 | 0 | 100.0 | |
| All triple | 48 | 28 | 63.2 | 81 | 13 | 86.1 | |
| Mixed | Wild type/single | 1 | 0 | 100.0 | 1 | 0 | 100.0 |
| Double | 5 | 0 | 100.0 | 6 | 1 | 85.7 | |
| Triple | 0 | 0 | 3 | 0 | 100.0 | ||
| Mixed | 3 | 0 | 100.0 | 9 | 0 | 100.0 | |
| All mixed | 9 | 0 | 100 | 19 | 1 | 95 | |
| Total | 122 | 46 | 72.6 | 158 | 20 | 88.8 | |
a
One patient in each group received a blood transfusion.