TABLE 4.
Classification of regulated genes in ciprofloxacin-resistant mutants according to COGs
| Categorya | No. of genes regulated |
|||
|---|---|---|---|---|
| 104-cip activated | 104-cip repressed | 5408-cip activated | 5408-cip repressed | |
| Energy production and conversion | 11 | 8 | 5 | 7 |
| Carbohydrate transport and metabolism | 3 | 7 | 0 | 14 |
| Amino acid transport and metabolism | 4 | 3 | 2 | 10 |
| Coenzyme transport and metabolism | 2 | 0 | 0 | 0 |
| Inorganic ion transport and metabolism | 1 | 0 | 1 | 0 |
| Translation, ribosomal structure, and biogenesis | 0 | 0 | 3 | 0 |
| Transcription | 1 | 0 | 2 | 3 |
| Replication, recombination, and repair | 1 | 0 | 0 | 0 |
| Defense mechanisms | 2 | 0 | 2 | 0 |
| Signal transduction mechanisms | 0 | 1 | 0 | 1 |
| Cell wall/membrane/ envelope biogenesis | 1 | 1 | 0 | 3 |
| Cell motility | 0 | 3 | 0 | 26 |
| Posttranslational modification, protein turnover, and chaperones | 3 | 1 | 0 | 1 |
| General function prediction only | 1 | 0 | 1 | 4 |
| Function unknown | 2 | 0 | 3 | 1 |
| No COGb | 0 | 8 | 1 | 7 |
| Total | 32 | 32 | 20 | 77 |
a
Genes were classified according to COGs as defined at http://www.ncbi.nlm.nih.gov/COG/grace/fiew.cgi.
b
Repressed genes in 104-cip and 5408-cip were all SPI-1 genes. The activated gene in 5408-cip is the outer membrane protease gene ompX.