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. 2009 Nov 16;54(1):440–451. doi: 10.1128/AAC.00769-09

TABLE 3.

Differential expression of genes selected for further analysis upon S. pneumoniae treatment for different times with bacitracin, nisin, and LL-37a

TIGR4 locus tag D39 locus tag Putative/predicted function Gene Fold induction upon exposure for indicated time (min) to:
Bacitracin
 Nisin
 LL-37
15 30 15 30 15 30
SP0385 SPD0350 Membrane protein 2.1 NDE NDE NDE 1.5 1.6
SP0386 SPD0351 Sensor histidine kinase hk03 2.4 NDE NDE NDE 1.5 1.7
SP0387 SPD0352 DNA-binding response regulator rr03 2.1 NDE NDE NDE 1.5 1.5
SP0525 SPD0467 Regulatory protein blpS NDE NDE NDE NDE 1.6 1.8
SP0526 SPD0468 Response regulator blpR NDE NDE NDE NDE 1.5 1.6
SP0527 SPD0469 Histidine kinase blpH NDE NDE NDE NDE 1.5 1.8
SP0528 SPD0470 Peptide pheromone blpC NDE NDE NDE NDE NDE 1.8
SP0529 SPD0471 ABC transporter, permease protein blpB NDE NDE NDE NDE 1.7 2.2
SP0530 SPD0472 ABC transporter, ATP-binding protein blpA NDE NDE NDE NDE 3.4 3.6
SP0533 SPD0046b Bacteriocin blpK NDE NDE NDE NDE 1.5 1.5
SP0545 SPD0473 CAAX protease blpY NDE NDE NDE NDE 5.0 5.9
SP0546 SPD0474 Immunity protein blpZ NDE NDE NDE NDE 3.5 3.8
SP0547 SPD0475 CAAX protease NDE NDE NDE NDE 3.7 4
SP0785 SPD0686 RND efflux-like protein 1.8 2.1 NDE NDE 4.1 5.5
SP0786 SPD0687 ABC transporter, ATP-binding protein 1.9 2.3 NDE NDE 5.1 5.0
SP0787 SPD0688 ABC transporter, permease protein 1.9 2.4 NDE NDE 4.6 6.1
SP0912 SPD0804 ABC transporter, ATP-binding protein 8.2 8.7 9.1 6 NDE NDE
SP0913 SPD0805 ABC transporter, permease protein 12.4 9.6 13.3 11.8 1.9 1.8
SP1714 SPD1524 GntR transcriptional regulator 2.9 NDE NDE NDE 7.2 9.1
SP1715 SPD1525-1526c ABC transporter, ATP-binding protein 2.3 NDE NDE NDE 11.4 13
a

Genes were selected for further analysis based on a Bayes P value of ≤0.0001 and ≤0.8- and ≥1.2-fold change after 15 min and 30 min with bacitracin, nisin, and LL-37. NDE, not significantly differentially expressed.

b

blpU encodes a homolog of SP0533. D39 does not posses blpK, but part of the amplicon sequence of SP0533 is identical to that of SPD0046.

c

The SP1715 amplicon on the array is homologous only to SPD1525; there is no information on the transcript levels of SPD1526.