TABLE 4.
Univariate Cox model of in-hospital mortality
| Variablea | Univariate HRb | P | 95% CI |
|---|---|---|---|
| Age (per yr) | 1.027 | 0.033 | 1.002-1.052 |
| Sex (female) | 1.257 | 0.578 | 0.562-2.812 |
| Race (nonwhite) | 0.695 | 0.447 | 0.273-1.773 |
| Underlying cancer (hematologic malignancy) | 0.619 | 0.397 | 0.204-1.879 |
| Central venous catheter removal | 0.549 | 0.170 | 0.233-1.292 |
| APACHE III score (per point) | 1.021 | 0.039 | 1.001-1.042 |
| Acute renal failure | 2.001 | 0.100 | 0.875-4.615 |
| Neutropenia (ANC, <500 cells/μl) | 0.566 | 0.457 | 0.126-2.535 |
| Organism (non-C. albicans) | 1.419 | 0.444 | 0.579-3.476 |
| Inappropriate therapy | −c | − | − |
| Total time (per h) | 1.013 | 0.023 | 1.002-1.025 |
| Incubation period (per h) | 1.025 | 0.001 | 1.011-1.040 |
| Provider notification period (per h) | 0.516 | 0.391 | 0.114-2.338 |
| Antifungal initiation period (per h) | 0.989 | 0.562 | 0.954-1.026 |
a
APACHE, Acute Physiology and Chronic Health Evaluation; ANC, absolute neutrophil count.
b
HR, hazard ratio.
c
−, hazard ratio estimates could not be calculated, because there were no cases of inappropriate therapy among the 31 episodes of candidemia evaluated.