TABLE 5.
Amino acid residue substitution | MMC99 μg/ml |
||
---|---|---|---|
E. coli | S. aureus | C. albicans | |
Modified HLBD1 | |||
Q22→A | >100 | 100 | >200 |
N26→A | 100 | 50 | 37 |
Q24→K | 12 | 25 | 50 |
HLBD1 | 50 | 50 | 200 |
Peptides were incubated with E. coli O6K5, S. aureus 1800, or C. albicans in BP. The peptides were diluted in twofold steps, starting at 100 or 200 μg/ml (C. albicans). Each sample was run in duplicate, and the experiment was repeated once.