. Author manuscript; available in PMC: 2010 Dec 1.

Published in final edited form as: Cancer Prev Res (Phila). 2009 Dec 1;2(12):1076–1087. doi: 10.1158/1940-6207.CAPR-09-0034

Table 3.

Gene expression changes in CR vs. AL and CR+EX vs. AL

		Fold change
Gene category/name	Gene description	CR vs. AL	CR+EX vs. AL
Cell cycle regulation and proliferation

Wee1^b	Wee1-like protein kinase	4.84^a	3.63^a
Ccng1^b	Cyclin-G1	1.69^a	1.52
Hspa9a^b	Heat shock protein 9A	2.51^a	1.48
Mycn^b	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	2.01	2.44^a
Ccnl2^c	cyclin L2	0.61^a	0.80
Ccnd1^c	cyclin D1	0.91	0.65^a

Differentiation and morphogenesis

GHr^b	Growth hormone receptor	1.81^a	1.55^a
stk16/Krct^b	Stk16 serine/threonine kinase 16	1.52^a	1.27^a
Hspa9a^b	Heat shock protein 9A	2.51^a	1.48
Cd24a^c	CD24a antigen	0.58^a	0.59^a
Cldn3^c	Claudin 3	0.63	0.60^a
Cldn4^c	Claudin 4	0.63	0.52^a
Prlr^c	Prolactin receptor	0.59	0.66^a

Apoptosis

Dapk1^b	Death associated protein kinase 1	1.82^a	1.62
Casp7^b	Caspase 7	1.61^a	1.40

DNA Repair/Response to DNA damage stimulus

Rad23a^b	RAD23a homolog (S. cerevisiae)	1.95^a	1.21
GADD45^c	growth arrest and DNA-damage-inducible 45β	0.48^a	0.40^a

Lipid metabolism and biosynthesis

Cyp51^b	cytochrome P450, family 51	1.60^a	1.80a
Gpam^b	glycerol-3-phosphate acyltransferase, mitochondrial	2.60^a	1.51
Lipg^b	lipase, endothelial	2.05^a	2.04
Fads2^b	fatty acid desaturase 2	1.93a	1.53
Fabp5^b	fatty acid binding protein 5, epidermal	2.53^a	2.40a
Pcx^b	pyruvate carboxylase	3.02^a	1.82^a
Ptdss2^b	phosphatidylserine synthase 2	2.14^a	1.30
Acaa2^b	acetyl-Coenzyme A acyltransferase 2	1.77^a	1.32
Pitpnb^b	phosphatidylinositol transfer protein β	1.87^a	1.64
Hsd17b12^b	hydroxysteroid (17-β) dehydrogenase 12	1.91^a	1.65^a
Elovl5^b	ELOVL family member 5, elongation of long chain fatty acids	1.56^a	1.52^a
Elovl6b	ELOVL family member 6, elongation of long chain fatty acids	2.18^a	1.91^a
Acot3^b	acyl-CoA thioesterase 3	1.99^a	1.52^a
Ptges^b	prostaglandin E synthase	1.99^a	1.71
Dgat2^b	diacylglycerol O-acyltransferase 2	1.79^a	1.37
Pmvk^b	phosphomevalonate kinase	1.71^a	1.82
Aacs^b	acetoacetyl-CoA synthetase	1.92^a	1.83
Acly^b	ATP citrate lyase	3.19^a	2.49
Fdps^b	farnesyl diphosphate synthetase	2.20^a	1.81
Acaa1^b	acetyl-Coenzyme A acyltransferase 1	1.70^a	1.38
Plce1^b	phospholipase C, epsilon 1	1.46	1.52^a
Mogat2^b	monoacylglycerol O-acyltransferase 2	1.46	2.16^a
Ptgds^c	prostaglandin D2 synthase (brain)	0.42^a	0.49^a

WNT pathway

Wisp2^b	WNT1 inducible signaling pathway protein 2	1.70^a	1.62^a
Frzb^b	frizzled-related protein	2.07^a	1.87
Ctnnb1^b	catenin (cadherin associated protein) β1	1.61^a	1.12
Apcdd1^c	adenomatosis polyposis coli down-regulated 1	0.59^a	0.55^a
Nlk^c	nemo like kinase	0.47^a	0.44^a
Wnt4^c	frizzled-related protein	0.69	0.60^a

MAP kinase pathway

Mapk6^b	Mitogen - activated protein kinase 6	2.70^a	1.95
Mapk8ip1^b	Mitogen - activated protein kinase 8 interacting protein 1	2.52^a	1.70
Mapk14^b	Mitogen - activated protein kinase 14	2.16^a	1.15

IGF-1 pathway

Igfbp4^b	insulin-like growth factor binding protein 4	2.77^a	1.75
Igfals^b	insulin-like growth factor binding protein, acid labile subunit	3.23^a	3.07^a

Other pathways

Camk2d^b	calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 3	1.62^a	1.43
Lep^c	leptin	0.23^a	0.26

genes altered by ≥ 1.5 fold (p ≤ 0.005)

genes up-regulated

genes down-regulated