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. Author manuscript; available in PMC: 2009 Dec 28.
Published in final edited form as: Pharmacol Ther. 2008 Jul 12;119(3):340–354. doi: 10.1016/j.pharmthera.2008.06.002

Fig. 2.

Fig. 2

Schematic presentation of the RyR2 channel complex. The domain structure of RyR2 with sites of interaction with auxiliary proteins and phosphorylation sites. Two major divergent regions located in the cytosolic portion are indicated. Calsequestrin, junctin, and triadin, proteins interacting with RyR and between themselves and RyR2 in the SR, are shown. PP, protein phosphatase; P, phosphorylation sites; CaM, calmodulin; CaMKII, calmodulin-dependent protein kinase II. Adapted from Gyorke and Terentyev, 2008.