Figure 2.

(A) Using B2 as a probe, we screened a human fetal brain cDNA library to obtain the full-length sequence of the ETO-binding protein, HuN-CoR. Shown is the complete amino acid sequence (GenBank accession no. AF044209). (B) The structure of the murine N-CoR (Mu N-CoR) can be divided into domains that mediate repression (RI, RII, RIII) (17), interact with the nuclear receptor (NRI, NRII) (17), or interact with the Sin3 corepressor complex (SIDI, SIDII) (15). By comparison with the functional domains of murine N-CoR, the ETO-binding domain of HuN-CoR lies between SIDI and SIDII and roughly corresponds to RIII.