TABLE 2.

Renal functional data in four groups of neonatal white New Zealand rabbits, exposed to an acute intravenous stat dose of NSAIDs. Groups A and B received 40 mg/kg body weight of acetylsalicylic acid (ASA), group C received 0.2 mg/kg body weight of ibuprofen and group D received 2 mg/kg body weight of indomethacin. The data are presented as mean percentage changes (Δ%) of the experimental data after the administration of one of the NSAIDs versus the control data in the same animal group

Treatment group	Age	UV (Δ%)	GFR (Δ%)	RBF (Δ%)	RVR
Group A – ASA	7 days	−41	−34	−52	+153
Group B – ASA	12 weeks	−5*	−22†	−16†	+20*
Group C – ibuprofen	7 days	−38	−36	−36	+61
Group D – indomethacin	7 days	−42	−45	−45	+55

^*P<0.001 versus ASA 7days;

^†P<0.01 versus ASA 7days. GFR Glomerular filtration rate (measured as inulin clearance); RBF renal blood flow (measured as para-aminohippuric acid [PAH] clearance equals renal plasma flow [RPF] with correction of the hematocrit [Htc] as follows: Renal blood flow [RBF]=RPF[1-Htc]); RVR Renal vascular resistance (calculated as mean arterial pressure divided by RBF); UV Urine volume