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. 2009 Dec 14;120(1):127–141. doi: 10.1172/JCI40027

Figure 7. Inhibition of autophagy by CQ addition sensitizes cells to hypoxia.

Figure 7

(A) Growth curves under normoxic and moderately hypoxic (0.2% O2) conditions showed that CQ addition selectively inhibited cell proliferation in U373, HT29, and HCT116 cells under hypoxic conditions (0.2% O2). Lower right: Quantification of the CQ-mediated inhibition of cell proliferation during normoxic and hypoxic conditions. n = 3, mean ± SEM. (B and C) Clonogenic survival after hypoxic (<0.02% O2) exposure with or without the addition of CQ in HT29 and U373 cells (B) or HCT116-pCDNA3 and HCT116–pCDNA3-eIF2α(S51A) cells (C). n = 3, mean ± SEM.