Figure 2. Cardiomyocyte-specific deletion of Klf5 did not alter pressure overload–induced hypertrophy.

Klf5^fl/fl and Klf5^fl/fl;αMHC-Cre mice were subjected to LI-TAC or sham operation. (A) Representative low-magnification views of H&E-stained heart sections 2 weeks after LI-TAC. Scale bar: 1 mm. (B and C) Heart weight/body weight ratios (B) and relative cross-sectional areas of cardiomyocytes normalized to those obtained from Klf5^fl/fl mice subjected to sham operations (C). (D) Fractional areas of fibrosis. *P < 0.01 versus sham control of the same genotype. n = 7.