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. 2009 Dec 21;120(1):254–265. doi: 10.1172/JCI40295

Figure 8. An IGF-1 receptor antagonist aggravates heart failure induced by severe pressure overload.

Figure 8

(A) Kaplan-Meier survival analysis of wild-type mice treated with vehicle or JB1, a peptide IGF-1 receptor antagonist, after HI-TAC. n = 10 in each group. *P < 0.001 versus vehicle. (B) Representative photographs of lungs taken 1 week after the operations. Note the severe lung edema in JB1-treated mice subjected to HI-TAC. (C) Lung weights in vehicle-treated and JB1-treated groups 1 week after the operations. n = 5 in each group. (D) Representative low-magnification views of H&E-stained heart sections 1 week after the operations. Scale bars: 1 mm. (E) Heart weights. (F) Echocardiographic analysis carried out 1 week after the operation. *P < 0.05 versus sham controls in the same treatment group; #P < 0.05 versus vehicle controls subjected to HI-TAC.